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Faqe e re: {{drugbox|Watchedfields = changed | verifiedrevid = 410160712 | | IUPAC_name = 2-acetoxybenzoic acid | OtherNames = Acetylsalicylic acid | image = Aspirin-skeletal.svg | image2 = Aspirin-...
 
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Rreshti 63:
Aspirin was the first discovered member of the class of drugs known as [[nonsteroidal anti-inflammatory drugs]] (NSAIDs), not all of which are salicylates, although they all have similar effects and most have inhibition of the enzyme [[cyclooxygenase]] as their [[nonsteroidal anti-inflammatory drugs#Mechanism of action|mechanism of action]]. Today, aspirin is one of the most widely used medications in the world, with an estimated 40,000 [[tonnes]] of it being consumed each year.<ref name='cox3article'>{{Cite journal|title=Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?|journal=Proc Natl Acad Sci USA|year=2002|coauthors=Warner TD, Mitchell JA.|volume=99|issue=21|pages=13371–3|pmid=12374850 |url=http://www.pnas.org/cgi/content/extract/99/21/13371|doi=10.1073/pnas.222543099|author=Warner, T. D.|pmc=129677}}</ref> In countries where ''Aspirin'' is a registered [[trademark]] owned by [[Bayer]], the generic term is ''acetylsalicylic acid'' (ASA).<ref>http://www.wordconstructions.com/articles/health/aspirin.html</ref><ref>http://www.inta.org/index.php?option=com_content&task=view&id=202&Itemid=126&getcontent=5</ref>
 
==HistoryHistoria==
{{Main|History of aspirin}}
Plant extracts, including [[willow]] [[bark]] and [[spiraea]], of which salicylic acid was the active ingredient, had been known to help heal headaches, pains and fevers since antiquity. The father of modern medicine, [[Hippocrates]], who lived sometime between 460 B.C and 377 B.C., left historical records of pain relief treatments, including the use of powder made from the bark and leaves of the willow tree to help heal headaches, pains and fevers.<ref>[http://inventors.about.com/library/inventors/blaspirin.htm History of aspirin]</ref>
Rreshti 76:
The popularity of aspirin declined after the market releases of [[paracetamol]] (acetaminophen) in 1956 and [[ibuprofen]] in 1969.<ref>Jeffreys, ''Aspirin'', pp. 212–217</ref> In the 1960s and 1970s, [[John Robert Vane|John Vane]] and others discovered the basic mechanism of aspirin's effects, while clinical trials and other studies from the 1960s to the 1980s established aspirin's efficacy as an anticlotting agent that reduces the risk of clotting diseases.<ref>Jeffreys, ''Aspirin'', pp. 226–231</ref> Aspirin sales revived considerably in the last decades of the 20th century, and remain strong in the 21st century, because of its widespread use as a preventive treatment for [[heart attack]]s and [[stroke]]s.<ref>Jeffreys, ''Aspirin'', pp. 267–269</ref>
 
===Trademark inne mostshume countriesvende===
As part of [[World War I reparations|war reparations]] specified in the 1919 [[Treaty of Versailles]] following Germany's surrender after [[World War I]], Aspirin (along with [[heroin]]) lost its status as a registered trademark in [[France]], [[Russia]], the [[United Kingdom]], and the [[United States]], where it became a generic name.<ref>
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