lomitapide

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komponim kimik

External resources

NDF-RT ID	N0000186142^[1]
Freebase ID	/m/05h4tv6^[2]
Reaxys registry number	13754976^[3]
PubChem CID	9853053^[4]^[5]
DSSTOX compound identifier	DTXCID3093785
UniChem compound ID	58406^[6]
LiverTox ID	Lomitapide
KEGG ID	D09637^[3]
ChEMBL ID	CHEMBL354541^[7]
InChIKey	MBBCVAKAJPKAKM-UHFFFAOYSA-N^[4]^[8]
DrugBank ID	DB08827^[5]
ChEBI ID	72297^[7]^[9] mapping relation type: përputhje e përpiktë
WikiProjectMed ID	Lomitapide
UNII	82KUB0583F^[1]^[5]
Probes And Drugs ID	PD009190
kodi ATC	C10AX12^[10]
SureChEMBL ID	SCHEMBL304604^[11]^[5]
numri CAS	182431-12-5^[1]^[12]
UMLS CUI	C2827241^[1]
DSSTox substance ID	DTXSID50171294^[13]^[5]
Guide to Pharmacology Ligand ID	7439^[14]
MedlinePlus drug identifier	a614008
InChI	InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)^[4]
PatientsLikeMe treatment ID	lomitapide
HSDB ID	8218^[15]
ChemSpider ID	8028764^[16]
Microsoft Academic ID	2776346971
DrugCentral ID	4721^[6]
Human Metabolome Database ID	HMDB0254156^[11]^[5]
RxNorm ID	1364479^[1]

instancë e

type of chemical entity

nënklasë e

përbërje kimike

përdor

Barnat

strukturë kimike

masa

693,279±0 dalton^[4]

formula kimike

C₃₉H₃₇F₆N₃O₂^[4]

kanonikja SMILES

C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F^[4]

defined daily dose

40 milligram^[17]

route of administration: oral administration

active ingredient in

Lojuxta^[18]

Juxtapid^[19]

World Health Organisation international non-proprietary name

lomitapide^[3]

medical condition treated

lipedema^[20]

significant drug interaction

itraconazole^[21]

side effect: hepatotoxicity

reagon fizikisht me

Microsomal triglyceride transfer protein^[22]

subjekti ka rol: reaction inhibitor

pregnancy category

US pregnancy category X

LiverTox likelihood score

LiverTox toxicity likelihood category C^[23]

subjekti ka rol

xenobiotic-transporting ATPase inhibitor^[24]

kategoria në Commons

Lomitapide

Reference

^ ^a ^b ^c ^d ^e Global Substance Registration System, 18 nëntor 2016, anglisht, lomitapide, 82KUB0583F
^ Freebase Data Dumps, 28 tetor 2013
^ ^a ^b ^c ChEBI, 3 tetor 2016, anglisht, lomitapide, 72297
^ ^a ^b ^c ^d ^e ^f PubChem, 18 nëntor 2016, anglisht, 9853053, Lomitapide
^ ^a ^b ^c ^d ^e ^f MBBCVAKAJPKAKM-UHFFFAOYSA-N, InChIKey
^ ^a ^b UniChem
^ ^a ^b ChEMBL, 18 nëntor 2016, anglisht, LOMITAPIDE, CHEMBL354541
^ ChEBI release 2020-09-01
^ InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49), International Chemical Identifier
^ DrugBank, anglisht, 17 nëntor 2015, 08827, Lomitapide
^ ^a ^b inferred from InChIKey
^ CAS Common Chemistry, 9 prill 2021, https://commonchemistry.cas.org/detail?cas_rn=182431-12-5, MBBCVAKAJPKAKM-UHFFFAOYSA-N
^ Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard
^ IUPHAR/BPS Guide to PHARMACOLOGY, 18 nëntor 2016, anglisht, 7439, lomitapide
^ Hazardous Substances Data Bank, 10 maj 2021, 28 tetor 2019, Lomitapide, 8218
^ ChemSpider, 18 nëntor 2016, anglisht, 8028764, Lomitapide
^ https://www.whocc.no/atc_ddd_index/?code=C10AX12
^ http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/002578/human_med_001668.jsp, 22 mars 2017, EMEA/H/C/002578
^ RxNorm, 1364485, 14 shkurt 2018
^ Drug Indications Extracted from FAERS, 2 tetor 2018
^ A reference set of clinically relevant adverse drug-drug interactions, hypothetically
^ Open Targets Platform, 14 gusht 2023, https://platform.opentargets.org/drug/CHEMBL354541
^ LiverTox, 8 prill 2021, https://www.ncbi.nlm.nih.gov/books/n/livertox/Lomitapide, 20 maj 2019
^ N0000186142, 5 mars 2018, NDF-RT

[r8d4eab47-1] Global Substance Registration System, 18 nëntor 2016, anglisht, lomitapide, 82KUB0583F

[r9fac6bd0-2] Freebase Data Dumps, 28 tetor 2013

[r051b502c-3] ChEBI, 3 tetor 2016, anglisht, lomitapide, 72297

[rf5a5445a-4] ^ ^a ^b ^c ^d ^e ^f PubChem, 18 nëntor 2016, anglisht, 9853053, Lomitapide

[r431946e2-5] ^ ^a ^b ^c ^d ^e ^f MBBCVAKAJPKAKM-UHFFFAOYSA-N, InChIKey

[rb4997d09-6] UniChem

[rfd475c6e-7] ChEMBL, 18 nëntor 2016, anglisht, LOMITAPIDE, CHEMBL354541

[rdb8780da-8] ChEBI release 2020-09-01

[ra49fa15a-9] InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49), International Chemical Identifier

[r19ddc1c0-10] DrugBank, anglisht, 17 nëntor 2015, 08827, Lomitapide

[r2758fec3-11] rred from InChIKey

[rfe8c4855-12] CAS Common Chemistry, 9 prill 2021, https://commonchemistry.cas.org/detail?cas_rn=182431-12-5, MBBCVAKAJPKAKM-UHFFFAOYSA-N

[r76075370-13] Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

[r651bb529-14] IUPHAR/BPS Guide to PHARMACOLOGY, 18 nëntor 2016, anglisht, 7439, lomitapide

[recad8675-15] Hazardous Substances Data Bank, 10 maj 2021, 28 tetor 2019, Lomitapide, 8218

[r8c2105c3-16] ChemSpider, 18 nëntor 2016, anglisht, 8028764, Lomitapide

[rf563cc54-17] ttps://www.whocc.no/atc_ddd_index/?code=C10AX12

[r11fa78bd-18] ttp://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/002578/human_med_001668.jsp, 22 mars 2017, EMEA/H/C/002578

[rc0b74956-19] RxNorm, 1364485, 14 shkurt 2018

[rdc52db13-20] Drug Indications Extracted from FAERS, 2 tetor 2018

[rcbd4a3da-21] A reference set of clinically relevant adverse drug-drug interactions, hypothetically

[rfdd72545-22] Open Targets Platform, 14 gusht 2023, https://platform.opentargets.org/drug/CHEMBL354541

[r23164ea3-23] LiverTox, 8 prill 2021, https://www.ncbi.nlm.nih.gov/books/n/livertox/Lomitapide, 20 maj 2019

[r3abc7083-24] N0000186142, 5 mars 2018, NDF-RT

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