natamycin
komponim kimik
instancë e
type of chemical entity
nënklasë e
polyene macrolide
strukturë kimike
masa
665,305 dalton[2]
stereoisomer of
formula kimike
C₃₃H₄₇NO₁₃[2]
kanonikja SMILES
CC1CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC3C(O3)C=CC(=O)O1)O)O)O)C(=O)O)OC4C(C(C(C(O4)C)O)N)O[2]
isomeric SMILES
C[C@@H]1C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@@H]3[C@H](O3)/C=C/C(=O)O1)O)O)O)C(=O)O)O[C@H]4[C@H]([C@H]([C@@H]([C@H](O4)C)O)N)O[2]
defined daily dose
active ingredient in
Natacyn[28]
World Health Organisation international non-proprietary name
natamycin[6]
found in taxon
Streptomyces natalensis[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51]
Streptomyces gilvosporeus[52][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50]
Streptomyces chattanoogensis[30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50]
Streptomyces lydicus[30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50]
Streptomyces[53]
medical condition treated
conjunctivitis[54]
coccidioidomycosis[54]
aspergillosis[54]
fungal infectious disease[54]
blepharitis[54]
microsporidiosis[54]
blastomycosis[54]
cryptococcosis[54]
sporotrichosis[54]
histoplasmosis[54]
keratitis[54]
kategoria në Commons
Natamycin
Reference
- ^ Freebase Data Dumps, 28 tetor 2013
- ^ a b c d e f g PubChem, 17 nëntor 2016, anglisht, 5284447, pimaricin
- ^ a b c d e f NCXMLFZGDNKEPB-FFPOYIOWSA-N, InChIKey
- ^ a b c d NCXMLFZGDNKEPB-BQGNJOPGSA-N, InChIKey
- ^ a b UniChem
- ^ a b ChEMBL, 19 janar 2016, anglisht, Natamycin, CHEMBL1200656
- ^ a b c d e DrugBank, anglisht, 17 nëntor 2015, 00826, Natamycin
- ^ a b c d e f Global Substance Registration System, 17 nëntor 2016, anglisht, natamycin, 8O0C852CPO
- ^ OpenAlex, 26 janar 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
- ^ ChEMBL, 17 nëntor 2016, anglisht, NATAMYCIN, CHEMBL1200656
- ^ CAS Common Chemistry, 10 prill 2021, https://commonchemistry.cas.org/detail?cas_rn=7681-93-8, NCXMLFZGDNKEPB-FFPOYIOWSA-N
- ^ a b c d e inferred from InChIKey
- ^ ChEBI release 2020-09-01
- ^ ChEBI release 2019-10-02
- ^ ChEBI release 2021-03-01
- ^ InChI=1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1, International Chemical Identifier
- ^ CosIng database, 28 dhjetor 2019, 91607, NATAMYCIN, CAS no.: 7681-93-8
- ^ https://list.essentialmeds.org/medicines/230, eEML - Electronic Essential Medicines List, 23 tetor 2021
- ^ Great Norwegian Encyclopedia, 5 qershor 2020
- ^ Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard
- ^ ECHA Substance Infocard database, 27 dhjetor 2018, 100.028.803, Natamycin, CAS no.: 7681-93-8
- ^ ChemSpider, 17 nëntor 2016, anglisht, 10468784, Natamycin
- ^ DrugBank, anglisht, 17 nëntor 2015, Natamycin, 00826
- ^ inferred from InChI
- ^ https://www.whocc.no/atc_ddd_index/?code=G01AA02
- ^ https://www.whocc.no/atc_ddd_index/?code=A07AA03
- ^ https://www.whocc.no/atc_ddd_index/?code=A01AB10
- ^ RxNorm, 202743, 14 shkurt 2018
- ^ The structure of the macrolide antibiotic pimaricin
- ^ a b c d Enhancement of natamycin production on Streptomyces gilvosporeus by chromosomal integration of the Vitreoscilla hemoglobin gene (vgb).
- ^ a b c d Bidirectional Regulation of AdpAch in Controlling the Expression of scnRI and scnRII in the Natamycin Biosynthesis of Streptomyces chattanoogensis L10.
- ^ a b c d Improvement of Natamycin Production by Cholesterol Oxidase Overexpression in Streptomyces gilvosporeus
- ^ a b c d Multiple transporters are involved in natamycin efflux in Streptomyces chattanoogensis L10.
- ^ a b c d Improvement of natamycin production by engineering of phosphopantetheinyl transferases in Streptomyces chattanoogensis L10.
- ^ a b c d Enhanced Natamycin production by Streptomyces natalensis in shake-flasks and stirred tank bioreactor under batch and fed-batch conditions
- ^ a b c d Physicochemical and microbial responses of Streptomyces natalensis HW-2 to fungal elicitor
- ^ a b c d Production of natamycin by Streptomyces gilvosporeus Z28 through solid-state fermentation using agro-industrial residues
- ^ a b c d Rational construction of genome-reduced and high-efficient industrial Streptomyces chassis based on multiple comparative genomic approaches
- ^ a b c d Complete Genome Sequence of the High-Natamycin-Producing Strain Streptomyces gilvosporeus F607.
- ^ a b c d WblAch, a pivotal activator of natamycin biosynthesis and morphological differentiation in Streptomyces chattanoogensis L10, is positively regulated by AdpAch
- ^ a b c d Effects of cultivation conditions on the production of natamycin with Streptomyces gilvosporeus LK-196.
- ^ a b c d Genome mining and homologous comparison strategy for digging exporters contributing self-resistance in natamycin-producing Streptomyces strains
- ^ a b c d Solubility properties and diffusional extraction behavior of natamycin from Streptomyces gilvosporeus biomass
- ^ a b c d Genome-wide analysis of the regulation of pimaricin production in Streptomyces natalensis by reactive oxygen species.
- ^ a b c d Construction of a Streptomyces lydicus A01 transformant with a chit42 gene from Trichoderma harzianum P1 and evaluation of its biocontrol activity against Botrytis cinerea.
- ^ a b c d Influence of fungal elicitors on biosynthesis of natamycin by Streptomyces natalensis HW-2
- ^ a b c d SlnM gene overexpression with different promoters on natamycin production in Streptomyces lydicus A02.
- ^ a b c d Characterization of type II thioesterases involved in natamycin biosynthesis in Streptomyces chattanoogensis L10.
- ^ a b c d Biosynthesis regulation of natamycin production from Streptomyces natalensis HDMNTE-01 enhanced by response surface methodology.
- ^ a b c d Identification of a secondary metabolism-responsive promoter by proteomics for over-production of natamycin in Streptomyces
- ^ A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis
- ^ Iteratively improving natamycin production in Streptomyces gilvosporeus by a large operon-reporter based strategy
- ^ AB-400, a new tetraene macrolide isolated from Streptomyces costae
- ^ a b c d e f g h i j k l N0000146913, 13 dhjetor 2016, anglisht, NDF-RT
- ^ a b c Inxight: Drugs Database, 2 nëntor 2018, https://drugs.ncats.io/drug/8O0C852CPO, http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050514s009lbl.pdf
- ^ a b c Medical Subject Headings, 15 mars 2018, D010866