Interleukin 6
proteinë
pjesë e
interleukin-6[13]
four-helical cytokine-like, core[13]
Interleukin-6/GCSF/MGF, conserved site, protein family[14]
found in taxon
encoded by
IL6[11]
molecular function
cell component
biological process
përputhje e saktë
ka pjesë
Interleukin-6/GCSF/MGF, conserved site[13]
Reference
- ^ Freebase Data Dumps, 28 tetor 2013
- ^ a b c d e NCBI Gene, 30 maj 2020, 3569
- ^ a b c d e f g h i j P05231, 9 gusht 2016, anglisht, UniProt
- ^ Ensembl Release 99, ENSP00000385675
- ^ Ensembl Release 99, ENSP00000258743
- ^ Ensembl Release 99, ENSP00000384928
- ^ Ensembl Release 99, ENSP00000385043
- ^ Ensembl Release 99, ENSP00000385227
- ^ Ensembl Release 99, ENSP00000385718
- ^ Ensembl Release 99, ENSP00000405150
- ^ a b c d UniProt, 13 nëntor 2019, P05231
- ^ OpenAlex, 26 janar 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
- ^ a b c InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P05231
- ^ inferred from protein domain or family
- ^ British Heart Foundation, 27 mars 2018, Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor, GOA, NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b c d e f g British Heart Foundation, 27 mars 2018, GOA, ISS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b c d e GOA, 27 mars 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, IEA
- ^ a b c d InterPro, 27 mars 2018, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b British Heart Foundation, 27 mars 2018, Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b c British Heart Foundation, 27 mars 2018, Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ Proteome Inc., 27 mars 2018, Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6), GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b c d British Heart Foundation, 27 mars 2018, Molecular cloning and expression of an IL-6 signal transducer, gp130, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b c British Heart Foundation, 27 mars 2018, Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ Proteome Inc., 27 mars 2018, Loss of IL-6 receptor expression in cervical carcinoma cells inhibits autocrine IL-6 stimulation: abrogation of constitutive monocyte chemoattractant protein-1 production, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ Marked cell-type-specific differences in glycosylation of human interleukin-6, GOA, 27 mars 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, NAS
- ^ British Heart Foundation, 27 mars 2018, Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ IntAct protein interaction database, 27 mars 2018, Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ IntAct protein interaction database, 27 mars 2018, Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ IntAct protein interaction database, 27 mars 2018, A human protein-protein interaction network: a resource for annotating the proteome, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ IntAct protein interaction database, 27 mars 2018, Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ IntAct protein interaction database, 27 mars 2018, Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b c d e Reactome, 27 mars 2018, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ British Heart Foundation, 27 mars 2018, Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ British Heart Foundation, 27 mars 2018, Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b c British Heart Foundation, 27 mars 2018, Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ British Heart Foundation, 27 mars 2018, Interleukin 6 induces the expression of vascular endothelial growth factor, GOA, IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription, GOA, 27 mars 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, IDA
- ^ British Heart Foundation, 27 mars 2018, Platelet activation induced by interleukin-6: evidence for a mechanism involving arachidonic acid metabolism, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ British Heart Foundation, 27 mars 2018, Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin, GOA, IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b British Heart Foundation, 27 mars 2018, Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling, GOA, NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ British Heart Foundation, 27 mars 2018, Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6, GOA, IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b c d British Heart Foundation, 27 mars 2018, Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b British Heart Foundation, 27 mars 2018, Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes, GOA, NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b c d Mouse Genome Informatics, 27 mars 2018, Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ British Heart Foundation, 27 mars 2018, Synergistic activation of human T cells by interleukin 1 and interleukin 6, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b c British Heart Foundation, 27 mars 2018, Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b British Heart Foundation, 27 mars 2018, Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b c d British Heart Foundation, 27 mars 2018, JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b British Heart Foundation, 27 mars 2018, Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE), GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ British Heart Foundation, 27 mars 2018, Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor, GOA, IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b British Heart Foundation, 27 mars 2018, Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b Interleukin-6 suppression of neutrophil apoptosis is neutrophil concentration dependent, GOA, 27 mars 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, IDA
- ^ British Heart Foundation, 27 mars 2018, Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ British Heart Foundation, 27 mars 2018, Interleukin 6 induces the expression of vascular endothelial growth factor, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ British Heart Foundation, 27 mars 2018, Interleukin-6 regulates pancreatic alpha-cell mass expansion, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ British Heart Foundation, 27 mars 2018, Interleukin-6 regulates pancreatic alpha-cell mass expansion, GOA, IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells, GOA, 27 mars 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, IDA
- ^ Gene Ontology Consortium, 27 mars 2018, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b British Heart Foundation, 27 mars 2018, Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ Proteome Inc., 27 mars 2018, Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma, GOA, 27 mars 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, IMP
- ^ B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma, GOA, 27 mars 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, IDA
- ^ a b British Heart Foundation, 27 mars 2018, STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ a b British Heart Foundation, 27 mars 2018, Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ British Heart Foundation, 27 mars 2018, IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ Mouse Genome Informatics, 27 mars 2018, SASH1 is a scaffold molecule in endothelial TLR4 signaling, GOA, IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ GOA, 27 mars 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ISS
- ^ a b British Heart Foundation, 27 mars 2018, Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ British Heart Foundation, 27 mars 2018, Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells, GOA, IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
- ^ Identifiers.org